Oat Beta-Glucan : The art of rejuvenation with Structural Repair
In the wide realm of skincare, we're always on the lookout for ingredients that make skin both beautiful and healthy. One such standout gaining popularity in the cosmetic world is “beta-glucan”, particularly when it comes from oats.
Oat beta-glucan is a natural powerhouse that not only treats skin well but also helps fix its structure, leaving it looking radiant and youthful.
Let's explore the magic of Oat Beta-Glucan and see how it can upgrade skincare...
Understanding Oat Beta-Glucan:
Beta-glucans are naturally occurring polysaccharides found in the cell walls of certain grains, fungi, and bacteria. Oat beta-glucan, in particular, is extracted from oats, making it a rich source of skin-loving nutrients.
What sets oat beta-glucan apart is its unique molecular structure, which boasts a high level of solubility and bioavailability, ensuring optimal absorption by the skin.
Oat β-glucan accelerates epidermal barrier repair. Dectin-1 is one of the β-glucan receptors and many biological functions of β-glucan are mediated by Dectin-1. Dectin-1 has been shown to promote wound healing by regulating the proliferation and migration of skin cells.
🌿In today's blog we will explain this mechanism
But first, we would like to talk about the benefits to the skin in general...
Skin Benefits of Oat Beta-Glucan
Deep Hydration
Oat beta-glucan is a humectant, meaning it attracts and retains moisture. It forms a protective film on the skin's surface, preventing water loss and keeping skin hydrated.
This makes it an excellent choice for individuals with dry or dehydrated skin.
Soothing Sensation
For those with sensitive or irritated skin, oat beta-glucan is a calming ally. Its anti-inflammatory properties help reduce redness and soothe irritated skin, providing relief to those dealing with conditions like eczema or rosacea.
Collagen Synthesis
Oat beta-glucan plays a vital role in stimulating collagen synthesis. Collagen is a key structural protein that maintains skin elasticity and firmness. By promoting collagen production, oat beta-glucan helps combat the signs of aging, such as fine lines and wrinkles.
And todays main topic...⭐
Structural Repair
One of the standout features of oat beta-glucan is its ability to support structural repair. When incorporated into skincare formulations, it aids in reinforcing the skin's natural barrier, promoting resilience and protecting against environmental stressors.
Its interaction with the dectin-1 receptor on fibroblasts plays a crucial role in this process.
Let's delve deeper into the mechanisms involved:
1. Binding to Dectin-1:
Oat beta-glucan possesses a unique β-(1,3)(1,4)-glycosidic linkage pattern that allows it to specifically bind to dectin-1, a C-type lectin receptor expressed on fibroblasts.
Dectin-1 recognizes the specific carbohydrate structure of oat beta-glucan, triggering downstream signaling pathways within the fibroblast.
2. Initiating Repair Mechanisms:
Dectin-1 activation triggers various signaling cascades, including the mitogen-activated protein kinase (MAPK) pathway and the nuclear factor-κB (NF-κB) pathway.
These pathways influence various cellular processes crucial for skin repair:
Proliferation and migration: Stimulates fibroblast proliferation and migration, essential for collagen synthesis and wound closure.
Collagen synthesis: Upregulates the production of collagen, the main structural protein of the skin, promoting tissue regeneration.
Angiogenesis: Enhances the formation of new blood vessels, providing vital nutrients and oxygen for healing.
Anti-inflammatory activity: Modulates the inflammatory response, preventing excessive inflammation that hinders repair.
Scientific studies support the involvement of dectin-1 in the wound-healing effects of Oat Beta-Glucan.
Blocking this receptor often eliminates the observed benefits.
Another study has shown that oat beta-glucan promotes collagen synthesis and fibroblast migration in a dectin-1-dependent manner.
We have some news...
Beta-Glucan in CalmActive Oat is a novel premium prebiotic for skin microbiome.
At Active Bioworks, our current research focuses on developing safe and effective ways to inhibit pro-inflammatory cytokines, bringing us one step closer to more effective methods for skin conditions associated with redness and inflammation.
With CalmActive Oat, we have taken the power of Avena Sativa Kernel ( oat ) through a rigorous bio-extraction process, resulting in a powerful formula that nourishes the skin's microbiome.
CalmActive Oat uses PRO-LYSATE® Technology with bioactive compounds to reduce inflammation and soothe the skin. The ß-glucan structure creates a fascinating three-dimensional network that absorbs water, leaving skin calm, rejuvenated and radiant.
With its Beta Glucan and Avenanthramides, CalmActive Oats suppresses the production of pro-inflammatory cytokines. Thanks to this amazing function, skin redness and irritation will be significantly reduced.
Conclusion:
Oat beta-glucan is a multitasking ingredient that not only nourishes and moisturizes the skin, but also aids in structural repair. With the power of nature and the transformative benefits of oat beta-glucan in your skincare routine, together we have unlocked the secret to radiant, healthy skin.
You can contact us to take advantage of these benefits and enrich your cosmetic formulations in this context.
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Have a nice and “beautiful” day!
Please don’t hesitate to reach us for more: hello@activebioworks.com
Sales Force, Active Bioworks
REFERENCES
Du, Bin, Zhaoxiang Bian, and Baojun Xu. "Skin health promotion effects of natural beta‐glucan derived from cereals and microorganisms: a review." Phytotherapy Research 28.2 (2014): 159-166.
Jing R, Fu M, Huang Y, et al. Oat β-glucan repairs the epidermal barrier by upregulating the levels of epidermal differentiation, cell-cell junctions, and lipids via Dectin-1. Br J Pharmacol. 2023.
Sahasrabudhe, Neha M., et al. "Endo-glucanase digestion of oat β-Glucan enhances Dectin-1 activation in human dendritic cells." Journal of functional foods 21 (2016): 104-112.
