Postbiotics, Lysates, Microbiome: Strategies for Barrier-Repair Products
Why Postbiotics & Lysates? — The market signal
Interest in postbiotics and fermented/lysate ingredients is accelerating across personal care and cosmetics. Market reports show the postbiotics segment expanding rapidly (double-digit CAGRs reported ), driven by demand for stable, safe microbiome-supporting actives that are easier to formulate than live probiotics. [1]
This creates an opportunity for brands to make claims that demonstrate microbiome awareness.
Scientific Background — What literature says?
Fermentation-derived ingredients (bioferments, lysates, filtrates) can deliver low-molecular-weight metabolites, peptides, vitamins and other cofactors that support skin barrier function, modulate inflammation, and provide antioxidant effects.
Recent reviews and experimental papers document multiple mechanisms by which postbiotic components benefit skin health — from barrier reinforcement to modulation of local immune responses — making them attractive for sensitive, reactive and ageing skin formulations.
Because postbiotics and lysates are non-viable (or processed extracts), they avoid many of the stability and regulatory complications of live probiotic claims.. Industry safety reviews are actively evaluating common ferment/ferment filtrate ingredients to guide safe use in products.
Ingredient spotlight — how to position our three lysate products:
1 — Lactobacillus Ferment Filtrate : ProFerment™ LB
Core story: gentle microbiome-supportive filtrate rich in postbiotic metabolites.
Mechanisms / benefits to highlight: supports microbiome balance, soothes reactive skin, helps to regulate surface microflora and support recovery after barrier stress.
Ideally paired with humectants, calming actives (beta-glucan, oat derivatives) and barrier lipids to amplify barrier repair claims. Stable across typical water-based emulsions and serums.
“Microbiome-supporting postbiotic filtrate,” “helps soothe and balance the skin surface,” “compatible with sensitive skin formulations.”
Application ideas: daily soothing serums, post-procedural recovery products, toners for sensitive or reactive lines.
Note : Lactobacillus-derived ferment products are often used for microbiome support and soothing; pair your claims with in-vitro/clinical data where possible. [2]
2 — Saccharomyces Ferment Lysate Filtrate : ProFerment™ SC
Core story: fermentation filtrate from Saccharomyces with tight-junction and antioxidant benefits.
Mechanisms / benefits to highlight: supports integrity, reduces oxidative stress and can improve skin texture and resilience — useful for barrier and anti-fatigue positioning.
Works well in both leave-on and wash-off formats; synergises with peptides, antioxidants (vitamin C derivatives), and niacinamide for barrier + brightening builds. Be mindful of pH compatibility depending on accompanying actives.
“supports epidermal barrier integrity,” “antioxidant and resilience support from biofermentation.”
Application ideas: morning serums that defend skin from environmental stress, night concentrates for barrier repair, multi-benefit creams.
Note : Saccharomyces extracts show supportive effects on barrier function and oxidative stress in published studies. [3]
3 - Bifida Ferment Lysate : ProLysate™ BIFIDA
Core story: clinically supported lysate for barrier reinforcement and sensitivity reduction.
Mechanisms / benefits to highlight: documented to strengthen barrier function, modulate inflammatory response and increase resilience to oxidative and irritant stressors. Ideal for sensitive, erythematous or reactive skin categories.
“support skin barrier resistance,” “helps to reduces sensitivity and improves barrier recovery”
Application ideas: sensitive skin lines, post-procedure care, daily barrier boosters.
Note : Several peer-reviewed studies report barrier reinforcement and immunomodulatory effects for Bifida ferment lysate. Use those studies when substantiating clinical claims. [4]
Curious how postbiotics can elevate your next launch? Contact Active Bioworks for technical datasheets, formulation support and sample requests — let’s co-create microbiome-smart skincare.
References
1 DELRAY BEACH, Fla., July 29, 2025 /PRNewswire/ -- According to MarketsandMarkets™, The postbiotics market.
2. Dou J, Feng N, Guo F, Chen Z, Liang J, Wang T, Guo X, Xu Z. Applications of Probiotic Constituents in Cosmetics. Molecules. 2023 Sep 22;28(19):6765. doi: 10.3390/molecules28196765. PMID: 37836607; PMCID: PMC10574390.
3. Gaspar LR, Camargo FB Jr, Gianeti MD, Maia Campos PM. Evaluation of dermatological effects of cosmetic formulations containing Saccharomyces cerevisiae extract and vitamins. Food Chem Toxicol. 2008 Nov;46(11):3493-500. doi: 10.1016/j.fct.2008.08.028. Epub 2008 Sep 2. PMID: 18804142.
4. Wang, Rui, et al. "The pivotal role of Bifida Ferment Lysate on reinforcing the skin barrier function and maintaining homeostasis of skin defenses in vitro." Journal of Cosmetic Dermatology 22.12 (2023): 3427-3435.
